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Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6)

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CHCM1; MIC25; Coiled-coil-helix cristae morphology protein 1; MICOS complex subunit MIC25

Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6)
CCC S848
HGNC 28184
MGI 1913348
PubMed 22228767
RGD 1304561
UniProt Q9BRQ6
CHCHD6, Contains 1 CHCH domain. Contains a myristylation motif followed by DUF domain and a CHCH domain. Over-expressed ChChd3 is localized only to mitochondria. Deletion of CHCH domain disrupts mitochondrial localization suggesting that CHCH domain is an essential targeting motif in ChChd3. In vitro protein import studies showed that in addition to cysteines in CHCH domain, myristoylation is also necessary for targeting the protein to the IM of mitochondria. Over-expressed ChChd3 in HEK 293 cells binds to PKA and shows a clear increase in phosphorylation at Thr10 upon stimulation with 8-CPT cAMP. Further, immunofluorescence and sub-cellular fractionation studies showed that the protein is phosphorylated in mitochondria and translocated to nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 6 (CHCHD6) ELISA Kit Customized Service Offer
  1. "CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology."J. Biol. Chem. 287:7411-7426(2012) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11."FEBS Lett. 581:3545-3549(2007) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Uniform nomenclature for the mitochondrial contact site and cristae organizing system." J. Cell Biol. 204:1083-1086(2014) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]