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Autophagy Related Protein 1 (ATG1)

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AUT3; CVT10; Cytoplasm To Vacuole Targeting Protein 10; Autophagy protein 3; Serine/threonine-protein kinase ATG1

Autophagy Related Protein 1 (ATG1)
CCC S871
PubMed 20953146
UniProt P53104
Wiki Atg1
Atg1 is an essential part of the core autophagic machinery, which triggers induction of autophagy and the Cvt pathway. Although changes in Atg1 phosphorylation and complex formation are thought to regulate its function, the mechanism of Atg1 kinase activation remains unclear. Two phosphorylation sites, threonine 226 and serine 230, are evolutionarily conserved and located in the activation loop of the amino terminal kinase domain of Atg1. These phosphorylation events are not required for Atg1 localization to the phagosome assembly site (PAS), or the proper assembly of the multisubunit Atg1 kinase complex and binding to its activator Atg13. However, mutation of either one of these sites results in a loss of Atg1 kinase activity and its function in autophagy and the Cvt pathway. phosphorylation of Atg1 on multiple sites provides critical mechanisms to regulate Atg1 function in autophagy and the Cvt pathway.

Organism species: S. cerevisiae (Yeast)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Autophagy Related Protein 1 (ATG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Autophagy Related Protein 1 (ATG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Autophagy Related Protein 1 (ATG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Autophagy Related Protein 1 (ATG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Autophagy Related Protein 1 (ATG1) ELISA Kit Customized Service Offer
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