≡

Aldo Keto Reductase Family 1, Member E1 (AKR1E1)

[Edit]

Akr1cl2; Akr1e1; 1,5-anhydro-D-fructose reductase; Aldo-keto reductase family 1 member C-like protein 2

Aldo Keto Reductase Family 1, Member E1 (AKR1E1)
CCC S888
MGI 1914758
PubMed 23660342
UniProt Q9DCT1
AKR1E1, Belongs to the aldo/keto reductase family. Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones.
The aldo-keto reductase family is a family of enzymes that includes a number of related monomeric NADPH-dependent oxidoreductases, such as aldehyde reductase, aldose reductase, prostaglandin F synthase, xylose reductase, rho crystallin, and many others. All possess a similar structure, with a beta-alpha-beta fold characteristic of nucleotide binding proteins. The fold comprises a parallel beta-8/alpha-8-barrel, which contains a novel NADP-binding motif. The binding site is located in a large, deep, elliptical pocket in the C-terminal end of the beta sheet, the substrate being bound in an extended conformation.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aldo Keto Reductase Family 1, Member E1 (AKR1E1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aldo Keto Reductase Family 1, Member E1 (AKR1E1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aldo Keto Reductase Family 1, Member E1 (AKR1E1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aldo Keto Reductase Family 1, Member E1 (AKR1E1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aldo Keto Reductase Family 1, Member E1 (AKR1E1) ELISA Kit Customized Service Offer
  1. "Characterization of a novel murine aldo-keto reductase."(In) Weiner H. (eds.);Enzymology and molecular biology of carbonyl metabolism 6, pp.1-1, Plenum Press, New York (1996)
  2. "The transcriptional landscape of the mammalian genome." Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Mouse AKR1E1 is an ortholog of pig liver NADPH dependent 1,5-anhydro-D-fructose reductase."Biosci. Biotechnol. Biochem. 72:872-876(2008) [PubMed] [Europe PMC] [Abstract]