Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2)
[Edit]Oatp1b2; Slc21a10; SLC21A6; LST-1; Liver-Specific Organic Anion Transporter 1; Solute Carrier Family 21 Member 10
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Slco1b2 mice were fertile, developed normally, and exhibited no overt phenotypic abnormalities. Expression of Oatp1a4 and Oatp2b1 but not Oatp1a1 was greater in female Slco1b2 mice, but expression of other non-OATP transporters did not significantly differ between wild-type and Slco1b2 male mice.
Total bilirubin level was elevated by 2-fold in the Slco1b2 mice despite the fact that liver enzymes ALT and AST were normal. Pharmacological characterization was carried out using two prototypical substrates of human OATP1B1 and -1B3, rifampin and pravastatin. This is the first report of altered drug disposition profile in the Slco1b2 knockout mice and suggests the utility of this model for understanding the in vivo role of hepatic OATP transporters in drug disposition.
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPS904Mu01 | Recombinant Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Solute Carrier Organic Anion Transporter Family, Member 1B2 (SLCO1B2) | ELISA Kit Customized Service Offer |
- "Full-length cDNA cloning and genomic organization of the mouse liver-specific organic anion transporter-1 (lst-1)."Biochem. Biophys. Res. Commun. 272:563-570(2000) [PubMed] [Europe PMC] [Abstract]
- "Large-scale phosphorylation analysis of mouse liver."Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
- "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]