≡

Immunoglobulin Heavy Variable (IgHV)

[Edit]

Ig heavy chain V-III region VH26

Immunoglobulin Heavy Variable (IgHV)
CCC S941
HGNC 5545
PubMed 10087405
UniProt P01764
Wiki IGHV
IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations of IGHV are associated with better responses to some treatments and with prolonged survival.
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by a C region gene, that provides effector or signaling functions. The heavy chain V region is encoded by 3 types of genes: V genes, joining (J) genes, and diversity (D) genes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Immunoglobulin Heavy Variable (IgHV) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Immunoglobulin Heavy Variable (IgHV) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Immunoglobulin Heavy Variable (IgHV) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Immunoglobulin Heavy Variable (IgHV) CLIA Kit Customized Service Offer
n/a ELISA Kit for Immunoglobulin Heavy Variable (IgHV) ELISA Kit Customized Service Offer
  1. "Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region."Proc. Natl. Acad. Sci. U.S.A. 77:6561-6565(1980) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein."Eur. J. Immunol. 23:846-851(1993) [PubMed] [Europe PMC] [Abstract]
  4. "Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain."Proc. Natl. Acad. Sci. U.S.A. 82:8624-8628(1985) [PubMed] [Europe PMC] [Abstract]