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Lethal Giant Larvae Homolog 2 (LLGL2)

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HGL; LGL2

Lethal Giant Larvae Homolog 2 (LLGL2)
CCC S946
HGNC 6629
MGI 1918843
PubMed 21606200
RGD 1560307
UniProt Q6P1M3
LLGL2 is a cortical cytoskeleton protein that is a part of a larger complex of proteins. The complex, which consists of LGN, PKC ι and PAR-6β, may play a role in ensuring the correct organization and orientation of bipolar spindles for normal cell division and for the initial phase of the establishment of epithelial cell polarity. In Drosophila melanogaster, LLGL2 is required in follicle cells for the differentiation of both stalk cells and posterior follicle cells. In humans, LLGL2 may be involved in cell proliferation control and tumorigenesis. Phosphorylation of LLGL2 is induced during cell polarization and may contribute to the segregation of LLGL2 from the PKC ι and PAR-6β complex. Overexpression of LLGL2 is thought to inhibit tight junction formation in cells. LLGL2 is expressed in the cytoplasm and localizes to the perinuclear structure of the cell.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lethal Giant Larvae Homolog 2 (LLGL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lethal Giant Larvae Homolog 2 (LLGL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lethal Giant Larvae Homolog 2 (LLGL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lethal Giant Larvae Homolog 2 (LLGL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lethal Giant Larvae Homolog 2 (LLGL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lethal Giant Larvae Homolog 2 (LLGL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lethal Giant Larvae Homolog 2 (LLGL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lethal Giant Larvae Homolog 2 (LLGL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lethal Giant Larvae Homolog 2 (LLGL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lethal Giant Larvae Homolog 2 (LLGL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lethal Giant Larvae Homolog 2 (LLGL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lethal Giant Larvae Homolog 2 (LLGL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lethal Giant Larvae Homolog 2 (LLGL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lethal Giant Larvae Homolog 2 (LLGL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lethal Giant Larvae Homolog 2 (LLGL2) ELISA Kit Customized Service Offer
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division."J. Biol. Chem. 280:6761-6765(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity."Curr. Biol. 13:734-743(2003) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Involvement of Lgl and Mahjong/VprBP in cell competition."PLoS Biol. 8:E1000422-E1000422(2010) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]