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Small Proline Rich Protein 2E (SPRR2E)

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Small Proline Rich Protein 2E (SPRR2E)
CCC T049
HGNC 11265
PubMed 12584609
UniProt P22531
SPRR2E belongs to the cornifin (SPRR) family. The small proline rich protein (SPRR) gene family encodes a conserved group of cornified envelope (CE) proteins that are part of the human epidermal differentiation complex (EDC). The formation of the cornified envelope during the late stages of epidermal differentiation is essential for epidermal barrier function and protects the body against environmental attack and water loss. Additionally, the expression of SPRR proteins is linked to keratinocyte terminal differentiation. The SPRR gene family, namely comprises three subclasses of genes, SPRR1, SPRR2 and SPRR3. SPRR1 is found predominantly in follicular epidermis and oral mucosa, SPRR2 is expressed coherently in follicular and interfollicular epidermis and SPRR3 is absent in epidermis and strongly expressed in internal squamous.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Proline Rich Protein 2E (SPRR2E) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Proline Rich Protein 2E (SPRR2E) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Proline Rich Protein 2E (SPRR2E) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Proline Rich Protein 2E (SPRR2E) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Proline Rich Protein 2E (SPRR2E) ELISA Kit Customized Service Offer
  1. "Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes."Mol. Cell. Biol. 8:2195-2203(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function."J. Biol. Chem. 276:19231-19237(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]