Zinc Finger Protein 28 (ZNF28)

The ZNF28 gene was amplified on the same samples to show the equal amount of cDNA. Belongs to the krueppel C2H2-type zinc-finger protein family.Contains 18 C2H2-type zinc fingers.Contains 1 KRAB domain

RNA-protein complexes have important functions in gene expression and regulation. Zinc fingers of the Cys-Cys-His-His (C₂H₂) class that bind RNA do so via contacts with amino acid side chains in the α-helical portion of the zinc finger, similar to their interaction with DNA. In general, two or more tandem zinc fingers are present in naturally occurring zinc finger proteins. In vitro selection and recombination techniques have isolated single zinc fingers that bind complex RNA structures with high affinity and specificity. These zinc fingers may ultimately find use as pharmaceutical or agricultural agents designed specifically to modify the function of cellular or viral RNA.