Protein Phosphatase 1, Regulatory Subunit 3G (PPP1R3G)

PPP1R3G encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. PPP1R3Fcontains 12 different gt-ag introns. Transcription produces 13 different mRNAs, 11 alternatively spliced variants and 2 unspliced forms. There are 3 probable alternative promotors, 2 non overlapping alternative last exons and 10 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 5 cassette exons, overlapping exons with different boundaries.