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Polo Like Kinase 1 Substrate 1 (PLK1S1)

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C20orf19; Kiz; Kizuna

Polo Like Kinase 1 Substrate 1 (PLK1S1)
CCC T351
HGNC 15865
MGI 2684960
PubMed 24680887
RGD 1307071
UniProt Q2M2Z5
A functional bipolar spindle is indispensible for the accurate segregation of chromosomes at mitosis. The centrosomal protein and polo-like kinase-1 (Plk1) substrate Kizuna (Kiz), has now been shown to have a novel function in maintaining spindle-pole integrity and spindle bipolarity.
Kizuna means 'bonds' in Japanese. Phosphorylation at Thr-379 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization.Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polo Like Kinase 1 Substrate 1 (PLK1S1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polo Like Kinase 1 Substrate 1 (PLK1S1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polo Like Kinase 1 Substrate 1 (PLK1S1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polo Like Kinase 1 Substrate 1 (PLK1S1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polo Like Kinase 1 Substrate 1 (PLK1S1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polo Like Kinase 1 Substrate 1 (PLK1S1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polo Like Kinase 1 Substrate 1 (PLK1S1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polo Like Kinase 1 Substrate 1 (PLK1S1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polo Like Kinase 1 Substrate 1 (PLK1S1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polo Like Kinase 1 Substrate 1 (PLK1S1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Polo Like Kinase 1 Substrate 1 (PLK1S1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Polo Like Kinase 1 Substrate 1 (PLK1S1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Polo Like Kinase 1 Substrate 1 (PLK1S1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Polo Like Kinase 1 Substrate 1 (PLK1S1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polo Like Kinase 1 Substrate 1 (PLK1S1) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity."Nat. Cell Biol. 8:1095-1101(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation."EMBO J. 28:2066-2076(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Whole-exome sequencing identifies KIZ as a ciliary gene associated with autosomal-recessive rod-cone dystrophy."Am. J. Hum. Genet. 94:625-633(2014) [PubMed] [Europe PMC] [Abstract]