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Ring Finger Protein 115 (RNF115)

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ZNF364; BCA2; E3 ubiquitin-protein ligase RNF115; Rabring 7

Ring Finger Protein 115 (RNF115)
CCC T417
HGNC 18154
MGI 1915095
PubMed 22850893
RGD 1305315
UniProt Q9Y4L5
Wiki ZNF364
BCA2 encodes an ORF of 304 aa and contains various distinct domains: a RING-H2 finger, a zinc finger, an AKT phosphorylation site and several SH3 domain binding motifs.Ubiquitination of wild-type, RING-H2 and AKT site mutants of BCA2 was tested in HEK293T cells transfected with Flag-tagged expression vectors. After immunoprecipitation with Flag-antibody the wt and mt BCA2 proteins were incubated with E1 and E2 enzymes and Ub, and analyzed by Western blotting.BCA2 maps to chromosome 1q21, which has been implicated in breast and other cancers.
BCA2 is a novel RING-type E3 ligase that is important for the homeostasis of proteins crucial to breast carcinogenesis and that BCA2 and partner proteins may provide novel targets to develop effective treatments for breast cancer.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 115 (RNF115) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 115 (RNF115) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 115 (RNF115) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 115 (RNF115) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 115 (RNF115) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 115 (RNF115) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 115 (RNF115) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 115 (RNF115) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 115 (RNF115) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 115 (RNF115) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer."Cancer Res. 65:10401-10412(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Novel RING E3 ubiquitin ligases in breast cancer."Neoplasia 8:689-695(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration."Mol. Cancer Res. 6:1385-1396(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor."J. Cell Sci. 126:1366-1380(2013) [PubMed] [Europe PMC] [Abstract]