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C-Type Lectin Domain Family 14, Member A (CLEC14A)

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C14orf27; EGFR5; Epidermal growth factor receptor 5

C-Type Lectin Domain Family 14, Member A (CLEC14A)
CCC T520
HGNC 19832
MGI 1914114
PubMed 23644659
RGD 1306232
UniProt Q86T13
Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion. Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined.
Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell-cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell-cell adhesion and angiogenesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 14, Member A (CLEC14A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 14, Member A (CLEC14A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 14, Member A (CLEC14A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 14, Member A (CLEC14A) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 14, Member A (CLEC14A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 14, Member A (CLEC14A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 14, Member A (CLEC14A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 14, Member A (CLEC14A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 14, Member A (CLEC14A) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 14, Member A (CLEC14A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant C-Type Lectin Domain Family 14, Member A (CLEC14A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to C-Type Lectin Domain Family 14, Member A (CLEC14A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to C-Type Lectin Domain Family 14, Member A (CLEC14A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for C-Type Lectin Domain Family 14, Member A (CLEC14A) CLIA Kit Customized Service Offer
n/a ELISA Kit for C-Type Lectin Domain Family 14, Member A (CLEC14A) ELISA Kit Customized Service Offer
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  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]