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Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2)

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Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2)
CCC T528
HGNC 19957
MGI 2144865
PubMed 23176824
RGD 1307503
UniProt O15040
TECPR2is a 1,411 amino acid protein that belongs to the WD repeat KIAA0329 family. TECPR2 contains three WD repeats, six TECPR repeats, and is encoded by a gene that maps to human chromosome 14q32.31. The WD40-repeat protein ATG16L1 and TECPR1 also associated with theCCT chaperonin complex implicated in the folding of WD40 proteins10.
Chromosome 14 houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder α1-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectonin Beta Propeller Repeat Containing Protein 2 (TECPR2) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Network organization of the human autophagy system."Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Mutation in TECPR2 reveals a role for autophagy in hereditary spastic paraparesis."Am. J. Hum. Genet. 91:1065-1072(2012) [PubMed] [Europe PMC] [Abstract]