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Keratin Associated Protein 12-3 (KRTAP12-3)

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High sulfur keratin-associated protein 12.3

Keratin Associated Protein 12-3 (KRTAP12-3)
CCC T556
HGNC 20531
UniProt P60328
KRTAP12-3 encodes a member of the keratin-associated protein (KAP) family. Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues.Interacts with hair keratins.
The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This gene encodes a member of the high sulfur KAP family. It is localized to a cluster of intronless KAPs at 21q22.3 which are located within the introns of the C21orf29 gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Keratin Associated Protein 12-3 (KRTAP12-3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Keratin Associated Protein 12-3 (KRTAP12-3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Keratin Associated Protein 12-3 (KRTAP12-3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Keratin Associated Protein 12-3 (KRTAP12-3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Keratin Associated Protein 12-3 (KRTAP12-3) ELISA Kit Customized Service Offer
  1. "A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3."Genomics 83:679-693(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21."J. Invest. Dermatol. 122:147-158(2004) [PubMed] [Europe PMC] [Abstract]