RNA Binding Motif Protein, Y-Linked Family 1, Member E (RBMY1E)

RBMY1E encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked.The RBMY1 proteins are encoded by strongly repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individues, and some of them may represent pseudogenes.