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AT Hook DNA Binding Motif Containing Protein 1 (AHDC1)

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AT Hook DNA Binding Motif Containing Protein 1 (AHDC1)
CCC T663
HGNC 25230
MGI 2444218
RGD 1310031
UniProt Q5TGY3
The rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The gene product has been provisionally designated AHDC1 pending further characterization.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for AT Hook DNA Binding Motif Containing Protein 1 (AHDC1) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Large-scale concatenation cDNA sequencing."Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "De novo truncating mutations in AHDC1 in individuals with syndromic expressive language delay, hypotonia, and sleep apnea." Am. J. Hum. Genet. 94:784-789(2014) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]