≡

Pre-mRNA Processing Factor 38A (PRPF38A)

[Edit]

Prp38

Pre-mRNA Processing Factor 38A (PRPF38A)
CCC T683
HGNC 25930
MGI 1916962
RGD 1311129
UniProt Q8NAV1
PRP38 has been genetically identified in a screen of temperature-sensitive mutants of Saccharomyces cerevisiae. Shifting temperature-sensitive prp38 cultures from 23 to 37oC prevents the first cleavage-ligation event in the excision of introns from mRNA precursors. In vitro splicing inactivation and complementation studies suggest that the PRP38-encoded factor functions, at least in part, after stable splicing complex formation. The PRP38 locus contains a 726-bp open reading frame coding for an acidic 28-kDa polypeptide (PRP38). While PRP38 lacks obvious structural similarity to previously defined splicing factors, heat inactivation of PRP38, PRP19, or any of the known U6 small nuclear ribonucleoprotein-associating proteins leads to a common, unexpected consequence: intracellular U6 small nuclear RNA levels decrease as splicing activity is lost.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 38A (PRPF38A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 38A (PRPF38A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 38A (PRPF38A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 38A (PRPF38A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 38A (PRPF38A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 38A (PRPF38A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 38A (PRPF38A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 38A (PRPF38A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 38A (PRPF38A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 38A (PRPF38A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 38A (PRPF38A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 38A (PRPF38A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 38A (PRPF38A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 38A (PRPF38A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 38A (PRPF38A) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]