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Coiled Coil Domain Containing Protein 99 (CCDC99)

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Spindly; Arsenite-related gene 1 protein; Rhabdomyosarcoma antigen MU-RMS-40.4A; Spindle apparatus coiled-coil domain-containing protein 1

Coiled Coil Domain Containing Protein 99 (CCDC99)
CCC T686
HGNC 26010
MGI 1917635
PubMed 24435511
RGD 1306908
UniProt Q96EA4
Spindly/CCDC99 Is Required for Efficient Chromosome Congression and Mitotic Checkpoint Regulation. Spindly recruits a fraction of cytoplasmic dynein to kinetochores for poleward movement of chromosomes and control of mitotic checkpoint signaling. Human Spindly is a cell cycle–regulated mitotic phosphoprotein that interacts with the Rod/ZW10/Zwilch (RZZ) complex. The kinetochore levels of Spindly are regulated by microtubule attachment and biorientation induced tension. Depletion of Spindly by RNAi, however, caused cells to arrest in prometaphase because of a delay in microtubule attachment. Spindly is not only required for kinetochore localization of dynein but is a functional component of a mechanism that couples dynein-dependent poleward movement of chromosomes to their efficient attachment to microtubules.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Domain Containing Protein 99 (CCDC99) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Domain Containing Protein 99 (CCDC99) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Domain Containing Protein 99 (CCDC99) Polyclonal Antibody Customized Service Offer
Assay Kits SET686Hu ELISA Kit for Coiled Coil Domain Containing Protein 99 (CCDC99) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Domain Containing Protein 99 (CCDC99) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Domain Containing Protein 99 (CCDC99) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Domain Containing Protein 99 (CCDC99) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Domain Containing Protein 99 (CCDC99) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Domain Containing Protein 99 (CCDC99) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Coiled Coil Domain Containing Protein 99 (CCDC99) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Coiled Coil Domain Containing Protein 99 (CCDC99) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Coiled Coil Domain Containing Protein 99 (CCDC99) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Coiled Coil Domain Containing Protein 99 (CCDC99) CLIA Kit Customized Service Offer
n/a ELISA Kit for Coiled Coil Domain Containing Protein 99 (CCDC99) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore."J. Cell Biol. 177:1005-1015(2007) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly."J. Cell Biol. 185:859-874(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]