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Ring Finger Protein 185 (RNF185)

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E3 ubiquitin-protein ligase RNF185

Ring Finger Protein 185 (RNF185)
CCC T705
HGNC 26783
MGI 1922078
PubMed 21931693
RGD 1564777
UniProt Q96GF1
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation.
RNF185is a 192 amino acid multi-pass membrane protein containing one RING-type zinc finger. Two RNF185 isoforms exist as a result of alternative splicing, and the gene encoding RNF185 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 185 (RNF185) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 185 (RNF185) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 185 (RNF185) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 185 (RNF185) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 185 (RNF185) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 185 (RNF185) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 185 (RNF185) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 185 (RNF185) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 185 (RNF185) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 185 (RNF185) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 185 (RNF185) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 185 (RNF185) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 185 (RNF185) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 185 (RNF185) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 185 (RNF185) ELISA Kit Customized Service Offer
  1. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1."PLoS ONE 6:E24367-E24367(2011) [PubMed] [Europe PMC] [Abstract]
  6. "RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)."J. Biol. Chem. 288:31177-31191(2013) [PubMed] [Europe PMC] [Abstract]