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THO Complex Subunit 6 (THOC6)

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WDR58; fSAP35; WD Repeat Domain 58; Functional Spliceosome-Associated Protein 35

THO Complex Subunit 6 (THOC6)
CCC T735
HGNC 28369
MGI 2677480
PubMed 23621916
RGD 708553
UniProt Q86W42
WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. is a 341 amino acid protein that contains seven WD-repeats and belongs to the WD-repeat THOC6 family. THOC6 is a component of the THO/TREX complex that is recruited to transcribed genes and travels along with RNA polymerase II (Pol II) during elongation, coupling elongating Pol II with RNA splicing and export factors. Multiple isoforms of THOC6 exist due to alternative splicing events.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant THO Complex Subunit 6 (THOC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to THO Complex Subunit 6 (THOC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to THO Complex Subunit 6 (THOC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for THO Complex Subunit 6 (THOC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for THO Complex Subunit 6 (THOC6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant THO Complex Subunit 6 (THOC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to THO Complex Subunit 6 (THOC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to THO Complex Subunit 6 (THOC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for THO Complex Subunit 6 (THOC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for THO Complex Subunit 6 (THOC6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant THO Complex Subunit 6 (THOC6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to THO Complex Subunit 6 (THOC6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to THO Complex Subunit 6 (THOC6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for THO Complex Subunit 6 (THOC6) CLIA Kit Customized Service Offer
n/a ELISA Kit for THO Complex Subunit 6 (THOC6) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Linking transcriptional elongation and messenger RNA export to metastatic breast cancers."Cancer Res. 65:3011-3016(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Recruitment of the human TREX complex to mRNA during splicing."Genes Dev. 19:1512-1517(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Human mRNA export machinery recruited to the 5' end of mRNA."Cell 127:1389-1400(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication."PLoS Pathog. 4:E1000194-E1000194(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Intellectual disability associated with a homozygous missense mutation in THOC6."Orphanet J. Rare Dis. 8:62-62(2013) [PubMed] [Europe PMC] [Abstract]