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DDHD Domain Containing Protein 2 (DDHD2)

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SAMWD1; SAM, WWE And DDHD Domain Containing 1

DDHD Domain Containing Protein 2 (DDHD2)
CCC T747
HGNC 29106
MGI 1919358
PubMed 23176823
UniProt O94830
Phospholipase that hydrolyzes preferentially phosphatidic acid and phosphatidylethanolamine. May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures.
DDHD2 belongs to the PA-PLA1 family. Phospholipase A1 (PLA1) is an enzyme that hydrolyzes the sn-1 fatty acids from phospholipids and produces 2-acyl-lysophospholipids. Although PLA1 activities are detected in many tissues and cell lines, a limited number of PLA1s have been purified and cloned so far. These include phosphatidylserine (PS)-specific PLA1 (PS-PLA1) from rat platelets, PLA1 from vespid venom, and phosphatidic acid (PA)-preferential PLA1 (PA-PLA1). Structurally, the former two PLA1s belong to the lipase family, where they form a subfamily among the lipase family.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDHD Domain Containing Protein 2 (DDHD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDHD Domain Containing Protein 2 (DDHD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDHD Domain Containing Protein 2 (DDHD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDHD Domain Containing Protein 2 (DDHD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDHD Domain Containing Protein 2 (DDHD2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DDHD Domain Containing Protein 2 (DDHD2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DDHD Domain Containing Protein 2 (DDHD2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DDHD Domain Containing Protein 2 (DDHD2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DDHD Domain Containing Protein 2 (DDHD2) CLIA Kit Customized Service Offer
n/a ELISA Kit for DDHD Domain Containing Protein 2 (DDHD2) ELISA Kit Customized Service Offer
  1. "A novel phospholipase A1 with sequence homology to a mammalian Sec23p-interacting protein, p125."J. Biol. Chem. 277:11329-11335(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "p125 is localized in endoplasmic reticulum exit sites and involved in their organization."J. Biol. Chem. 280:10141-10148(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Golgi-localized KIAA0725p regulates membrane trafficking from the Golgi apparatus to the plasma membrane in mammalian cells."FEBS Lett. 584:4389-4395(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Roles of SAM and DDHD domains in mammalian intracellular phospholipase A1 KIAA0725p."Biochim. Biophys. Acta 1823:930-939(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in DDHD2, encoding an intracellular phospholipase A(1), cause a recessive form of complex hereditary spastic paraplegia." Am. J. Hum. Genet. 91:1073-1081(2012) [PubMed] [Europe PMC] [Abstract]