≡

UBX Domain Protein 7 (UBXN7)

[Edit]

UBXN7

UBX Domain Protein 7 (UBXN7)
CCC T748
HGNC 29119
MGI 2146388
PubMed 22537386
RGD 1306346
UniProt O94888
p97 is an ATP-dependent chaperone that plays an important role in endoplasmic reticulum-associated degradation but whose connections to turnover of soluble proteins remain sparse. Binding of p97 to substrates is mediated by cofactors that contain ubiquitin-binding domains. The UBX proteins that bind ubiquitin conjugates also interact with dozens of E3 ubiquitin ligases, only one of which had been previously linked to p97. In particular, UBXD7 links p97 to the ubiquitin ligase CUL2/VHL and its substrate hypoxia-inducible factor 1alpha (HIF1alpha). Depletion of p97 leads to accumulation of endogenous HIF1alpha and increased expression of a HIF1alpha target gene. The large number of ubiquitin ligases found associated with UBX proteins suggests that p97 plays a far broader role than previously anticipated in the global regulation of protein turnover.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UBX Domain Protein 7 (UBXN7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UBX Domain Protein 7 (UBXN7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UBX Domain Protein 7 (UBXN7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UBX Domain Protein 7 (UBXN7) CLIA Kit Customized Service Offer
n/a ELISA Kit for UBX Domain Protein 7 (UBXN7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UBX Domain Protein 7 (UBXN7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UBX Domain Protein 7 (UBXN7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UBX Domain Protein 7 (UBXN7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UBX Domain Protein 7 (UBXN7) CLIA Kit Customized Service Offer
n/a ELISA Kit for UBX Domain Protein 7 (UBXN7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UBX Domain Protein 7 (UBXN7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UBX Domain Protein 7 (UBXN7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UBX Domain Protein 7 (UBXN7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UBX Domain Protein 7 (UBXN7) CLIA Kit Customized Service Offer
n/a ELISA Kit for UBX Domain Protein 7 (UBXN7) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  6. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1alpha accumulation."BMC Biol. 10:36-36(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Solution structure of the UBX domain of KIAA0794 protein."Submitted (NOV-2004) to the PDB data bank
  16. "Solution structure of the novel identified UBA-like domain in the N-terminal of human FAS associated factor 1 protein."Submitted (JUN-2006) to the PDB data bank
  17. "Solution structure of the UAS domain of human UBX domain-containing protein 7."Submitted (OCT-2006) to the PDB data bank