Scleraxis Homolog B (SCXB)

Basic helix-loop-helix transcription factor scleraxis is a protein that in humans is encoded by the SCXB gene. The scleraxis protein is a member of the basic-helix-loop-helix (bHLH) superfamily of transcription factors. Currently two genes (SCXA and SCXB respectively) have been identified to code for identical scleraxis proteins.

bHLH transcription factors have been shown to have a wide array of functions in developmental processes. More precisely, they have critical roles in the control of cellular differentiation, proliferation and regulation of oncogenesis.To date, 242 eukaryotic proteins belonging to the HLH superfamily have been reported. They have varied expression patterns in all eukaryotes from yeast to humans.