Tripartite Motif Containing Protein 43 (TRIM43)

Trim43a, Trim43b, and Trim43c, primarily based on the following sequence similarity searches. Top two hits were humanTRIM43 and a protein similar to human TRIM17; both proteins shared 41% identities and were mapped to Chromosome 2. The third hit was human TRIM11 that shared 36% identities and was mapped to Chromosome 11. When the human TRIM43 protein was searched against all the mouse proteins, TRIM43C,TRIM43A,TRIM43B were among the top hits, sharing 42% (TRIM43C) and 41% (TRIM43A and TRIM43B) identities with the human TRIM43 protein. The domain sequences of mouse TRIM43A protein showed a high conservation in RING (48.7%), Bbox (54.7%), and SPRY (50%) of the human TRIM43 protein. At the protein level, identities are 95% (TRIM43A vs TRIM43B), 92% (TRIM43A vs TRIM43C), and 94% (TRIM43B vs TRIM43C).