Preferentially Expressed Antigen Of Melanoma Family Member 14 (PRAMEF14)

Several tumor-associated antigen families, such as MAGE, GAGE, PRAME and BAGE, are of particular interest in tumor immunology because their expression, with exception of testis and fetal tissues, seems to be restricted to tumor cells.
PRAMEF14 is a 483 amino acid protein containing three LRR (leucine-rich) repeats and is a member of the PRAME family. Contains 2 LRR (leucine-rich) repeats. PRAMEF14 has homology to a melanoma-associated protein, PRAME. PRAME is a melanoma antigen recognized by cytotoxic T cells (CTLs) and is expressed in a variety of cancer cells, including leukemic cells. The PRAME gene is expressed at a high level in a very large fraction of tumors, such as melanomas, non small-cell lung carcinomas, sarcomas, head and neck tumors and renal carcinomas.