GRB2 Associated Binding Protein 4 (GAB4)
[Edit]Growth factor receptor bound protein 2-associated protein 4; GRB2-associated binder 2-like; GRB2-associated binder 4; GRB2-associated-binding protein 2-like
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GAB4 belongs to the GAB family.Contains 1 PH domain.Grb2-associated binder (Gab) family of scaffolding adaptor proteins coordinate signaling cascades downstream of growth factor and cytokine receptors. In the heart, among EGF family members, neuregulin-1beta (NRG-1beta, a paracrine factor produced from endothelium) induced remarkable tyrosine phosphorylation of Gab1 and Gab2 via erythroblastic leukemia viral oncogene (ErbB) receptors. Although DKO mice were viable, they exhibited marked ventricular dilatation and reduced contractility with aging. Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant GRB2 Associated Binding Protein 4 (GAB4) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to GRB2 Associated Binding Protein 4 (GAB4) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to GRB2 Associated Binding Protein 4 (GAB4) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for GRB2 Associated Binding Protein 4 (GAB4) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for GRB2 Associated Binding Protein 4 (GAB4) | ELISA Kit Customized Service Offer |