Forkhead Box D4 Like Protein 5 (FOXD4L5)

FOXD4L5 contains 1 fork-head DNA-binding domain. 5 FOXD4-like proteins (FOXD4L2, FOXD4L3, FOXD4L4, FOXD4L5 and FOXD4L6) are encoded by a strongly repeated region of the 9q12 chromosome region. They are very similar and it is therefore difficult to provide a clear and unambiguous protein sequence.

FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. FoxD4a and foxD4b mRNA was expressed in the leukemia cell lines KG-1, Kasumi, NB-4, HL-60, U937, THP-1, HEL, U266, Jurkat, and Raji. It has already been shown that winged helix factors are also involved in carcinogenesis. FOXD4a and FOXD4b may play a role in leukemogenesis.