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Ring Finger Protein 126 (RNF126)

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E3 ubiquitin-protein ligase RNF126

Ring Finger Protein 126 (RNF126)
CCC U043
HGNC 21151
MGI 1917544
PubMed 23026136
RGD 1306011
UniProt Q9BV68
RNF126 contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this protein has been shown to interact with Ube2l3/UbcM4, which is an ubiquitin-conjugating enzyme involved in embryonic development.
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family. A RING (Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a Cys3HisCys4 amino acid motif which binds two zinc cations.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 126 (RNF126) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 126 (RNF126) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 126 (RNF126) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 126 (RNF126) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 126 (RNF126) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 126 (RNF126) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 126 (RNF126) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 126 (RNF126) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 126 (RNF126) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 126 (RNF126) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 126 (RNF126) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 126 (RNF126) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 126 (RNF126) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 126 (RNF126) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 126 (RNF126) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  5. "E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation."Cancer Res. 73:385-394(2013) [PubMed] [Europe PMC] [Abstract]
  6. "The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor."J. Cell Sci. 126:1366-1380(2013) [PubMed] [Europe PMC] [Abstract]
  7. "Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase."Proc. Natl. Acad. Sci. U.S.A. 110:1029-1034(2013) [PubMed] [Europe PMC] [Abstract]
  8. "The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor."Exp. Cell Res. 320:219-232(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6."Mol. Cell 55:227-237(2014) [PubMed] [Europe PMC] [Abstract]