Zinc Finger Protein 454 (ZNF454)

ZNF454, May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family.Contains 12 C2H2-type zinc fingers.Contains 1 KRAB domain.
A zinc finger protein is a DNA-binding protein domain consisting of zinc fingers ranging from two in the Drosophila regulator ADR1, the more common three in mammalian Sp1 up to nine in TFIIIA. They occur in nature as the part of transcription factors conferring DNA sequence specificity as the DNA-binding domain. They have also found use in protein engineering due to their modularity and have prospects as components of tools for use in therapeutic gene modulation and zinc finger nucleases. Zinc finger protein consists of anti-parallel hairpin motif. It consists of 2 beta strands, one alpha helix and a hairpin structure.