ArfGAP With GTPase, ANK Repeat And PH Domain Containing Protein 8 (AGAP8)

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CTGLF5; Centaurin Gamma Like Family Member 5

ArfGAP With GTPase, ANK Repeat And PH Domain Containing Protein 8 (AGAP8)
AGAP8, Belongs to the centaurin gamma-like family.Contains 2 ANK repeats.Contains 1 Arf-GAP domain.Contains 1 PH domain.Centaurins are a family of proteins that contain GTPase-activating protein domains, with the gamma family members containing in addition a GTPase-like domain. Centaurins reside mainly in the nucleus and are known to activate phosphoinositide 3-kinase, a key regulator of cell proliferation, motility and vesicular trafficking.CENTG1 (centaurin gamma-1) the GTPase-like domain has broader trinucleotide specificity. Alterations within the G4 motif of CENTG1 from the highly conserved NKXD found in typical GTPases to TQDR result in the loss of specificity, a lower affinity for the nucleotides and higher turnover rates.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ArfGAP With GTPase, ANK Repeat And PH Domain Containing Protein 8 (AGAP8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ArfGAP With GTPase, ANK Repeat And PH Domain Containing Protein 8 (AGAP8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ArfGAP With GTPase, ANK Repeat And PH Domain Containing Protein 8 (AGAP8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ArfGAP With GTPase, ANK Repeat And PH Domain Containing Protein 8 (AGAP8) CLIA Kit Customized Service Offer
n/a ELISA Kit for ArfGAP With GTPase, ANK Repeat And PH Domain Containing Protein 8 (AGAP8) ELISA Kit Customized Service Offer
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  2. "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]