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CCR4 NOT Transcription Complex Subunit 10 (CNOT10)

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CCR4 NOT Transcription Complex Subunit 10 (CNOT10)
CCC U153
HGNC 23817
MGI 1926143
PubMed 23232451
RGD 1359219
UniProt Q9H9A5
Component of the CCR4-NOT complex at least composed of CNOT1, CNOT2, CNOT3, CNOT8, CNOT9, CNOT10 and TNKS1BP1. The Ccr4–Not complex has been implicated in the control of multiple steps of mRNA metabolism; however, its functions in transcription remain ambiguous. The discovery that Ccr4/Pop2 is the major cytoplasmic mRNA deadenylase and the detection of Not proteins within mRNA processing bodies have raised questions about the roles of the Ccr4–Not complex in transcription. The Ccr4–Not complex is targeted to the coding region of genes in a transcription-dependent manner similar to RNAPII and promotes elongation in vivo. Furthermore, Ccr4–Not interacts directly with elongating RNAPII complexes and stimulates transcription elongation of arrested polymerase in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 10 (CNOT10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 10 (CNOT10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 10 (CNOT10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 10 (CNOT10) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 10 (CNOT10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 10 (CNOT10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 10 (CNOT10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 10 (CNOT10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 10 (CNOT10) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 10 (CNOT10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant CCR4 NOT Transcription Complex Subunit 10 (CNOT10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to CCR4 NOT Transcription Complex Subunit 10 (CNOT10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to CCR4 NOT Transcription Complex Subunit 10 (CNOT10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for CCR4 NOT Transcription Complex Subunit 10 (CNOT10) CLIA Kit Customized Service Offer
n/a ELISA Kit for CCR4 NOT Transcription Complex Subunit 10 (CNOT10) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Human Ccr4-Not complexes contain variable deadenylase subunits."Biochem. J. 422:443-453(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex."RNA Biol. 10:267-276(2013) [PubMed] [Europe PMC] [Abstract]
  9. "Trypanosome CNOT10 is essential for the integrity of the NOT deadenylase complex and for degradation of many mRNAs."Nucleic Acids Res. 41:1211-1222(2013) [PubMed] [Europe PMC] [Abstract]
  10. "NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain."RNA Biol. 10:228-244(2013) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]