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Ring Finger Protein 169 (RNF169)

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E3 ubiquitin-protein ligase RNF169

Ring Finger Protein 169 (RNF169)
CCC U585
HGNC 26961
MGI 1920257
PubMed 22492721
UniProt Q8NCN4
RNF169 Contains 1 RING-type zinc finger. a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this protein has been shown to interact with Ube2l3/UbcM4, which is an ubiquitin-conjugating enzyme involved in embryonic development. E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Lacks the His residue in the RING-type domain 2 that is one of the conserved features of the family. A RING (Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a Cys3HisCys4 amino acid motif which binds two zinc cations.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 169 (RNF169) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 169 (RNF169) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 169 (RNF169) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 169 (RNF169) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 169 (RNF169) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 169 (RNF169) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 169 (RNF169) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 169 (RNF169) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 169 (RNF169) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 169 (RNF169) ELISA Kit Customized Service Offer
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  2. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Ring finger protein RNF169 antagonises the ubiquitin-dependent signaling cascade at sites of DNA Damage."J. Biol. Chem. 287:27715-27722(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks."J. Cell Biol. 197:189-199(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks."Mol. Cell 47:383-395(2012) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]