Bicaudal D Related Protein 1 (BICDR1)

BICDR1 Is an effector of the small GTPase Rab6 and key component of the molecular machinery that controls secretory vesicle transport in developing neurons. BICDR-1 has homology to Bicaudal-D family proteins, interacts with the dynein/dynactin retrograde motor complex and regulates the pericentrosomal localization of Rab6-positive secretory vesicles. BICDR-1 expression is high during early neuronal development and strongly declines during neurite outgrowth. In young neurons, BICDR-1 accumulates Rab6-positive secretory vesicles around the centrosome, restricts anterograde secretory transport and inhibits neuritogenesis. Later during development, BICDR-1 expression is strongly reduced which permits anterograde secretory transport required for neurite outgrowth.