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Non SMC Element 1 Homolog (NSMCE1)

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Non-Structural Naintenance Of Chromosomes Element 1

Non SMC Element 1 Homolog (NSMCE1)
CCC U975
HGNC 29897
MGI 1914961
RGD 1307760
UniProt Q8WV22
NSMCE1 Belongs to the NSE1 family.Contains 1 NSE1-type zinc finger.The structural maintenance of chromosomes (SMC) family of proteins play essential roles in genomic stability. SMC heterodimers are required for sister-chromatid cohesion, chromatin condensation, and DNA repair. The SMC heterodimers do not function alone and must associate with essential non-SMC subunits. Nse1 and Nse2 are essential proteins and conserved from yeast to man. Loss of Nse1 and Nse2 function leads to strikingly similar terminal phenotypes to those observed for Smc5–6 inactivation. In addition, cells expressing hypomorphic alleles of Nse1 and Nse2 are, like Smc5–6 mutants, hypersensitive to DNA damage. Epistasis analysis suggests that like Smc5–6, Nse1, and Nse2 function together with Rhp51 in the homologous recombination repair of DNA double strand breaks.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Non SMC Element 1 Homolog (NSMCE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Non SMC Element 1 Homolog (NSMCE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Non SMC Element 1 Homolog (NSMCE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Non SMC Element 1 Homolog (NSMCE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non SMC Element 1 Homolog (NSMCE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Non SMC Element 1 Homolog (NSMCE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Non SMC Element 1 Homolog (NSMCE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Non SMC Element 1 Homolog (NSMCE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Non SMC Element 1 Homolog (NSMCE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non SMC Element 1 Homolog (NSMCE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Non SMC Element 1 Homolog (NSMCE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Non SMC Element 1 Homolog (NSMCE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Non SMC Element 1 Homolog (NSMCE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Non SMC Element 1 Homolog (NSMCE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Non SMC Element 1 Homolog (NSMCE1) ELISA Kit Customized Service Offer
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Coordination of DNA damage responses via the Smc5/Smc6 complex."Mol. Cell. Biol. 24:662-674(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex."Mol. Cell. Biol. 28:1197-1206(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families."PLoS ONE 6:E17270-E17270(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Solution structure of the RING domain of the non-SMC element 1 protein."Submitted (NOV-2005) to the PDB data bank
  9. "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases."Mol. Cell 39:963-974(2010) [PubMed] [Europe PMC] [Abstract]