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COMM Domain Containing Protein 10 (COMMD10)

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COMM Domain Containing Protein 10 (COMMD10)
CCC U993
HGNC 30201
MGI 1916706
PubMed 22228203
RGD 1303015
UniProt Q9Y6G5
COMMD10 is a member of the newly discovered Copper Metabolism Murr1 Domain (COMMD) containing family of proteins. Interactions between COMMD2 and ENaC were examined using coimmunoprecipitation in COS-7 cells transiently transfected with ENaC and COMMD2. The functional effect of COMMD2 on ENaC was examined by comparing the amiloride-sensitive sodium current generated by ENaC-transfected FRT (Fisher rat thyroid) epithelial cells in the absence and presence of COMMD2.
COMMD2 interacts with ENaC, however the effect of this interaction is still unclear. It is possible that COMMD2 also regulates ENaC providing another mechanism by which body sodium homeostasis is maintained.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COMM Domain Containing Protein 10 (COMMD10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COMM Domain Containing Protein 10 (COMMD10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COMM Domain Containing Protein 10 (COMMD10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COMM Domain Containing Protein 10 (COMMD10) CLIA Kit Customized Service Offer
n/a ELISA Kit for COMM Domain Containing Protein 10 (COMMD10) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COMM Domain Containing Protein 10 (COMMD10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COMM Domain Containing Protein 10 (COMMD10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COMM Domain Containing Protein 10 (COMMD10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COMM Domain Containing Protein 10 (COMMD10) CLIA Kit Customized Service Offer
n/a ELISA Kit for COMM Domain Containing Protein 10 (COMMD10) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant COMM Domain Containing Protein 10 (COMMD10) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to COMM Domain Containing Protein 10 (COMMD10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to COMM Domain Containing Protein 10 (COMMD10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for COMM Domain Containing Protein 10 (COMMD10) CLIA Kit Customized Service Offer
n/a ELISA Kit for COMM Domain Containing Protein 10 (COMMD10) ELISA Kit Customized Service Offer
  1. "COMMD proteins, a novel family of structural and functional homologs of MURR1."J. Biol. Chem. 280:22222-22232(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding."J. Biol. Chem. 286:32355-32365(2011) [PubMed] [Europe PMC] [Abstract]
  8. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel."Am. J. Physiol. 305:F80-F89(2013) [PubMed] [Europe PMC] [Abstract]
  10. "CCDC22 deficiency in humans blunts activation of proinflammatory NF-kappaB signaling."J. Clin. Invest. 123:2244-2256(2013) [PubMed] [Europe PMC] [Abstract]
  11. "COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A." Mol. Biol. Cell 26:91-103(2015) [PubMed] [Europe PMC] [Abstract]