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Within Bgcn Homolog (WIBG)

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PYM; Partner of Y14 And Mago

Within Bgcn Homolog (WIBG)
CCC U997
HGNC 30258
MGI 1925678
RGD 1306096
UniProt Q9BRP8
WIBG Belongs to the wibg family.Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Within Bgcn Homolog (WIBG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Within Bgcn Homolog (WIBG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Within Bgcn Homolog (WIBG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Within Bgcn Homolog (WIBG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Within Bgcn Homolog (WIBG) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Within Bgcn Homolog (WIBG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Within Bgcn Homolog (WIBG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Within Bgcn Homolog (WIBG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Within Bgcn Homolog (WIBG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Within Bgcn Homolog (WIBG) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Within Bgcn Homolog (WIBG) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Within Bgcn Homolog (WIBG) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Within Bgcn Homolog (WIBG) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Within Bgcn Homolog (WIBG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Within Bgcn Homolog (WIBG) ELISA Kit Customized Service Offer
  1. "REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export."J. Cell Biol. 159:579-588(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex."EMBO Rep. 5:304-310(2004) [PubMed] [Europe PMC] [Abstract]
  6. "PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs."Nat. Struct. Mol. Biol. 14:1173-1179(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Disassembly of exon junction complexes by PYM."Cell 137:536-548(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]