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HD Domain Containing Protein 3 (HDDC3)

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MESH1; ppGppase; Penta-Phosphate Guanosine-3'-Pyrophosphohydrolase; Metazoan SpoT Homolog 1; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

HD Domain Containing Protein 3 (HDDC3)
CCC V021
HGNC 30522
MGI 1915945
PubMed 20818390
RGD 1311839
UniProt Q8N4P3
HDDC3 Belongs to the MESH1 family.Contains 1 HD domain.(p)ppGpp, guanosine pentaphosphate or tetraphosphate is an alarmone which is involved in the stringent response in bacteria, causing the inhibition of RNA synthesis when there is a shortage of amino acids present. This causes translation to decrease and the amino acids present are therefore conserved. Furthermore, genes for amino acid uptake (transport into the cell from surrounding media) and biosynthesis are also upregulated. However, (p)ppGpp influences the overall gene expression pattern in the cell so that many genes required for survival in stressful conditions are up-regulated. (p)ppGpp is created via pppGpp synthase, also known as RelA, and is converted from pppGpp to ppGpp via pppGpp phosphohydrolase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HD Domain Containing Protein 3 (HDDC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HD Domain Containing Protein 3 (HDDC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HD Domain Containing Protein 3 (HDDC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HD Domain Containing Protein 3 (HDDC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for HD Domain Containing Protein 3 (HDDC3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HD Domain Containing Protein 3 (HDDC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HD Domain Containing Protein 3 (HDDC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HD Domain Containing Protein 3 (HDDC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HD Domain Containing Protein 3 (HDDC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for HD Domain Containing Protein 3 (HDDC3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant HD Domain Containing Protein 3 (HDDC3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to HD Domain Containing Protein 3 (HDDC3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to HD Domain Containing Protein 3 (HDDC3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for HD Domain Containing Protein 3 (HDDC3) CLIA Kit Customized Service Offer
n/a ELISA Kit for HD Domain Containing Protein 3 (HDDC3) ELISA Kit Customized Service Offer
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  4. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses."Nat. Struct. Mol. Biol. 17:1188-1194(2010) [PubMed] [Europe PMC] [Abstract]