Ochnaflavone, a secondary plant secondary metabolite of the Biflavonoid family, has been widely investigated in past decades due to its unique ability to mediate biological activities, such as inhibition of phospholipase A2 and lymphocyte proliferation. Although Ochnaflavone has not been fully studied in the past decades, its protective role in plants/human body already attract scientists’ much attention, such as anti-atherogenic activity and anti-inflammatory activity. Anti-atherogenic activity: Atherogenesis refer to the formation of atheromas on arteries’ wall. It is believed that atherogenesis may be caused by an infection of the vascular smooth muscle cells. Find molecules that possess anti-proliferation activity of vascular smooth muscle cells seems a good strategy to treat Atherogenesis. In 2006, a research group from Korea found Ochnaflavone could inhibit tumor necrosis factor (TNF)-a-Induced Human vascular smooth muscle cells proliferation.
-V064.gif)