Extracellular Leucine Rich Repeat And Fibronectin Type III Domain Containing Protein 1 (ELFN1)

ELFN1 Contains 1 fibronectin type-III domain.Contains 5 LRR (leucine-rich) repeats.Contains 1 LRRCT domain. The Fibronectin type III domain is an evolutionary conserved protein domain that is widely found in animal proteins. The fibronectin protein in which this domain was first identified contains 16 copies of this domain.
The fibronectin type III repeat region is an approximately 100 amino acid domain, different tandem repeats of which contain binding sites for DNA, heparin and the cell surface [1]. The superfamily of sequences believed to contain FnIII repeats represents 45 different families, the majority of which are involved in cell surface binding in some manner, or are receptor protein tyrosine kinases, or cytokine receptors.