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Lin-37 Homolog (LIN37)

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Antolefinin

Lin-37 Homolog (LIN37)
CCC V175
HGNC 33234
MGI 1922910
RGD 1308901
UniProt Q96GY3
LIN37 encodes a protein expressed in the eye.Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.
LIN complex (LINC), a human multiprotein complex that is required for transcriptional activation of G2/M genes. LINC is related to the recently identified dREAM and DRM complexes of Drosophila and C. elegans that contain homologs of the mammalian retinoblastoma tumor suppressor protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-37 Homolog (LIN37) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-37 Homolog (LIN37) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-37 Homolog (LIN37) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-37 Homolog (LIN37) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-37 Homolog (LIN37) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-37 Homolog (LIN37) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-37 Homolog (LIN37) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-37 Homolog (LIN37) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-37 Homolog (LIN37) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-37 Homolog (LIN37) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lin-37 Homolog (LIN37) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lin-37 Homolog (LIN37) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lin-37 Homolog (LIN37) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lin-37 Homolog (LIN37) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lin-37 Homolog (LIN37) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence."Mol. Cell 26:539-551(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]