SPINK14 Contains 1 Kazal-like domain. SPINK5 encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy.The entire precursor protein, as deduced from the nucleotide sequence of the cloned cDNA, includes 15 potential inhibitory domains, 13 of which exhibit a Kazal-type-derived 4-cysteine-residue pattern that represents a novel protein module of serine protease inhibitor. Northern blot analysis and RT-PCR detected expression of LEKTI in thymus, vaginal epithelium, Bartholin gland, oral mucosa, tonsil, and parathyroid gland.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Serine Peptidase Inhibitor Kazal Type 14 (SPINK14) | ELISA Kit Customized Service Offer |
- "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
- "A genomic analysis of rat proteases and protease inhibitors."Genome Res. 14:609-622(2004) [PubMed] [Europe PMC] [Abstract]