Chromosome 14 Open Reading Frame 102 (C14orf102)

C14orf102 is a 3810bp protein-encoding gene that is highly conserved among its non-distant orthologs. The protein contains five HAT (histone acetyltransferase) domains, a coiled coil domain, a domain of unknown function, a lysine-rich region, and a poly-lysine and serine region. Further post-translational modifications include phosphorylation and mono-methylation sites.[5] Because the protein is considered to be a part of a family of Up-frameshift proteins, it is expected to function in protein binding and to be located in the cytoplasm. Certain UPF proteins have been found to play a central role in the nonsense-mediated mRNA decay (NMD) pathway, which is responsible for identifying and degrading mRNA sequences that contain premature termination codons (PTCs) – sequences that encode truncated amino acid sequences.