Anisodamine (ADM)

Anisodamineis an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock in China. It is also a naturally occurring tropane alkaloid found in some plants of the Solanaceae family.Like atropine and scopolamine, anisodamine is a non-specific cholinergic antagonist exhibiting the usual spectrum of pharmacological effects of this drug class. It appears to be less potent and less toxic than atropine and displays less CNS toxicity than scopolamine. Anisodamine has been shown to interact with and disrupt liposome structure which may reflect its effects on cellular membranes. Experimental evidence implicates anisodamine as an anti-oxidant that may protect against free radical-induced cellular damage. Its cardiovascular properties include depression of cardiac conduction and the ability to protect against arrhythmia induced by various agents.