Trans-L-3-Hydroxyproline Dehydratase (L3HYPDH)

C14orf149 Belongs to the proline racemase family. In contrast to the T.cruzi enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue. The high conservation of the protein nevertheless suggests that it is nevertheless active.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on amino acids and derivatives. The systematic name of this enzyme class is proline racemase. This enzyme participates in arginine and proline metabolism. These enzymes catalyse the interconversion of L- and D-proline in bacteria. This family also contains several similar eukaryotic proteins including Q9NCP4 a sequence with B-cell mitogenic properties which has been characterised as a co-factor-independent proline racemase.