Chromosome 6 Open Reading Frame 58 (C6orf58)

C6orf58 is a protein which is subsequently secreted after cleavage of a signal peptide. DUF781, which is the singular identifiable domain in UPF0762, is tied to liver development in an orthologous protein in zebrafish. The function of the human UPF0762 is not yet well characterized. While there are 3 splice variants of C6orf58, only one encodes a good protein. In humans, C6orf58 expressed sequence tags were primarily detected in the larynx and trachea. Transcripts were only detected during the adult stage of development. Experimental microarray data, however, reveals additional regions of C6orf58 expression, namely in the salivary gland, thyroid, and small intestine.[5] Arsenic may also regulate expression as it increases methylation of the C6orf58 promoter.