Ashwin was isolated in a differential display screen for genes activated or up-regulated early in neural specification. ashwin is expressed maternally and zygotically, and it is up-regulated in the neural ectoderm after the midgastrula stage. It is expressed in the neural plate and later in the embryonic brain, eyes, and spinal cord. Overexpression of ashwin in whole embryos leads to anterior truncations and other defects. However, a second Organizer does not form, and the secondary axial structures may result from splitting of the Organizer, rather than axis duplication. Morpholino oligonucleotide-mediated reduction in ashwin expression leads to lethality or abnormalities in gastrulation, as well as significant apoptosis in midgastrula embryos. Apoptosis is also observed in midgastrula embryos overexpressing ashwin.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Ashwin (Ash) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Ashwin (Ash) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Ashwin (Ash) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Ashwin (Ash) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Ashwin (Ash) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Ashwin (Ash) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Ashwin (Ash) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Ashwin (Ash) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Ashwin (Ash) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Ashwin (Ash) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Ashwin (Ash) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Ashwin (Ash) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Ashwin (Ash) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Ashwin (Ash) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Ashwin (Ash) | ELISA Kit Customized Service Offer |
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