≡

WAS Protein Family Homolog 7 (WASH7)

[Edit]

SWIP; Strumpellin and WASH-interacting protein

WAS Protein Family Homolog 7 (WASH7)
CCC W520
HGNC 29174
MGI 2441787
RGD 1309995
UniProt Q2M389
WASH has 2 WASH homology domains (WHD1 and WHD2) in its N-terminal half. In its C-terminal half, WASH has a proline-rich stretch followed by a WH2 actin-binding domain (V), a central region (C), and an acidic stretch (A) that together form the VCA module found in all WASP proteins. Database analysis revealed WASH orthologs in both vertebrates and invertebrates. Vertebrates showed highest conservation in the WASH C terminus. Fluorescence-tagged WASH1 colocalized with cytoskeletal actin and accumulated in filopodia and lamellipodia. Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WAS Protein Family Homolog 7 (WASH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WAS Protein Family Homolog 7 (WASH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WAS Protein Family Homolog 7 (WASH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WAS Protein Family Homolog 7 (WASH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for WAS Protein Family Homolog 7 (WASH7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WAS Protein Family Homolog 7 (WASH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WAS Protein Family Homolog 7 (WASH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WAS Protein Family Homolog 7 (WASH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WAS Protein Family Homolog 7 (WASH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for WAS Protein Family Homolog 7 (WASH7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WAS Protein Family Homolog 7 (WASH7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WAS Protein Family Homolog 7 (WASH7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WAS Protein Family Homolog 7 (WASH7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WAS Protein Family Homolog 7 (WASH7) CLIA Kit Customized Service Offer
n/a ELISA Kit for WAS Protein Family Homolog 7 (WASH7) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex."Dev. Cell 17:712-723(2009) [PubMed] [Europe PMC] [Abstract]
  6. "WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes."Proc. Natl. Acad. Sci. U.S.A. 107:10442-10447(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a novel candidate gene for non-syndromic autosomal recessive intellectual disability: the WASH complex member SWIP."Hum. Mol. Genet. 20:2585-2590(2011) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIalpha."Mol. Biol. Cell 24:2269-2284(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]