≡

Apolipoprotein B Receptor (APOBR)

[Edit]

APOB48R; APOB100R; Apolipoprotein B48 Receptor; Apolipoprotein B100 Receptor

Apolipoprotein B Receptor (APOBR)
CCC W787
HGNC 24087
MGI 2176230
PubMed 10852956
RGD 1565169
UniProt Q0VD83
Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis.
Expressed in peripheral blood leukocytes > bone marrow = spleen > lymph node, and only faintly visible in appendix and thymus. Expressed in the brain, heart, kidney, liver, lung, pancreas, and placenta. Expressed primarily by reticuloendothelial cells: monocytes, macrophages, and endothelial cells. Expressed in atherosclerotic lesion foam cells

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein B Receptor (APOBR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein B Receptor (APOBR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein B Receptor (APOBR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein B Receptor (APOBR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein B Receptor (APOBR) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein B Receptor (APOBR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein B Receptor (APOBR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein B Receptor (APOBR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein B Receptor (APOBR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein B Receptor (APOBR) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apolipoprotein B Receptor (APOBR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apolipoprotein B Receptor (APOBR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apolipoprotein B Receptor (APOBR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apolipoprotein B Receptor (APOBR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apolipoprotein B Receptor (APOBR) ELISA Kit Customized Service Offer
  1. "A macrophage receptor for apolipoprotein B48: cloning, expression, and atherosclerosis."Proc. Natl. Acad. Sci. U.S.A. 97:7488-7493(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Antipeptide antibodies reveal interrelationships of MBP 200 and MBP 235: unique apoB-specific receptors for triglyceride-rich lipoproteins on human monocyte-macrophages."J. Lipid Res. 40:744-752(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Human THP-1 monocyte-macrophage membrane binding proteins: distinct receptor(s) for triglyceride-rich lipoproteins."Biochemistry 34:9126-9135(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Apolipoprotein B-48 or its apolipoprotein B-100 equivalent mediates the binding of triglyceride-rich lipoproteins to their unique human monocyte-macrophage receptor."Arterioscler. Thromb. Vasc. Biol. 18:968-976(1998) [PubMed] [Europe PMC] [Abstract]
  8. "PPAR(alpha) and PPAR(gamma) activators suppress the monocyte-macrophage apoB-48 receptor."J. Lipid Res. 44:1224-1231(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism."Arterioscler. Thromb. Vasc. Biol. 25:424-429(2005) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Association of nucleotide variations in the apolipoprotein B48 receptor gene (APOB48R) with hypercholesterolemia."J. Hum. Genet. 50:203-209(2005) [PubMed] [Europe PMC] [Abstract]