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Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25)

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GEFT; p63RhoGEF; RAC/CDC42 Exchange Factor; RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT; Guanine nucleotide exchange factor GEFT

Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25)
CCC W889
HGNC 30275
MGI 1277173
PubMed 12547822
RGD 735210
UniProt Q86VW2
The Rho family of small GTPases, including Rho, Rac, and Cdc42, play essential roles in diverse cellular functions.GEFT is highly expressed in the excitable tissues, including brain, heart, and muscle. Low or very little expression was detected in other nonexcitable tissues. Overexpression of GEFT leads to changes in cell morphology and actin cytoskeleton re-organization, including the formation of membrane microspikes, filopodia, and lamilliopodia. Furthermore, expression of GEFT in NIH3T3 cells promotes foci formation, cell proliferation, and cell migration, possibly through the activation of transcriptional factors involved in cell growth and proliferation.GEFT is a Rac/Cdc42-specific GEF protein that regulates cell morphology, cell proliferation, and transformation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) CLIA Kit Customized Service Offer
n/a ELISA Kit for Rho Guanine Nucleotide Exchange Factor 25 (ARHGEF25) ELISA Kit Customized Service Offer
  1. "A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration."J. Biol. Chem. 278:13207-13215(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere."J. Cell Sci. 115:629-640(2002) [PubMed] [Europe PMC] [Abstract]
  5. "p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene."Naunyn Schmiedebergs Arch. Pharmacol. 369:540-546(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA."J. Biol. Chem. 280:11134-11139(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT."Mol. Cell. Biol. 25:11089-11101(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain."J. Biol. Chem. 282:29201-29210(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs."Science 318:1923-1927(2007) [PubMed] [Europe PMC] [Abstract]