Oxyresveratrol is a potent tyrosinase inhibitor. Oxyresveratrol is a stilbenoid. It is found in the heartwood of Artocarpus lakoocha and in the traditional drug 'Puag-Haad' made from it. It is also the aglycone of mulberroside A, a compound found in Morus alba, the white mulberry. Oxyresveratrol is a potent antioxidant and free-radical scavenger found in mulberry wood (Morus alba L.) with demonstrated protective effects against cerebral ischemia. Cultures were treated with 25 μM, 50 μM or 100 μM oxyresveratrol at the time of injury. Trauma produced marked neuronal death when measured 24 h post-injury, and oxyresveratrol significantly inhibited this death. Microscopic examination of glia suggested signs of toxicity in cultures treated with 100 μM oxyresveratrol, as demonstrated by elevated S-100B protein release and a high proportion of cells with condensed nuclei.
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